Erythema induratum of Bazin in a child: evidence for a cell-mediated hyper-response to Mycobacterium tuberculosis

Pediatr Infect Dis J. 2009 Apr;28(4):326-8. doi: 10.1097/INF.0b013e31818e2ac0.

Abstract

Tuberculids are chronic nodular skin eruptions believed to be a systemic reaction to Mycobacterium tuberculosis. We report on a 6-year-old boy with tender subcutaneous lesions on his legs. A tuberculin skin test resulted in 2.5 cm of induration and an interferon-gamma releasing assay was also markedly positive. A diagnosis of erythema induratum of Bazin was confirmed on skin biopsy. The patient was successfully treated with multi-drug antituberculosis therapy.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antitubercular Agents / therapeutic use
  • Biopsy
  • Child
  • Erythema Induratum / diagnosis*
  • Erythema Induratum / drug therapy
  • Erythema Induratum / immunology
  • Erythema Induratum / microbiology
  • Exanthema / microbiology
  • Humans
  • Interferon-gamma / blood
  • Leg
  • Male
  • Mycobacterium tuberculosis / immunology
  • Mycobacterium tuberculosis / isolation & purification
  • Polymerase Chain Reaction

Substances

  • Antitubercular Agents
  • Interferon-gamma