Abstract
The synthesis of several (2-oxaadamant-1-yl)amines is reported. They were evaluated as NMDA receptor antagonists and several of them were more active than amantadine, but none was more potent than memantine. None of the tested compounds displayed antiviral activity. Two of the derivatives showed a significant level of trypanocidal activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adamantane / analogs & derivatives*
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Adamantane / chemical synthesis
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Adamantane / pharmacology*
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Amines / chemical synthesis*
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Amines / pharmacology*
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Animals
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Antiviral Agents / chemical synthesis
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Antiviral Agents / pharmacology
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Cell Culture Techniques
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Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors
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Receptors, N-Methyl-D-Aspartate / metabolism
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Trypanocidal Agents / chemical synthesis
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Trypanocidal Agents / pharmacology
Substances
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Amines
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Antiviral Agents
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Receptors, N-Methyl-D-Aspartate
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Trypanocidal Agents
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Adamantane