Direct and short-time uptake of [70]fullerene into the cell membrane using an exchange reaction from a [70]fullerene-gamma-cyclodextrin complex and the resulting photodynamic activity

Atsushi Ikeda; Masashi Matsumoto; Motofusa Akiyama; Jun-ichi Kikuchi; Takuya Ogawa; Tatsuo Takeya

doi:10.1039/b820768b

Direct and short-time uptake of [70]fullerene into the cell membrane using an exchange reaction from a [70]fullerene-gamma-cyclodextrin complex and the resulting photodynamic activity

Chem Commun (Camb). 2009 Mar 28:(12):1547-9. doi: 10.1039/b820768b. Epub 2009 Jan 29.

Authors

Atsushi Ikeda¹, Masashi Matsumoto, Motofusa Akiyama, Jun-ichi Kikuchi, Takuya Ogawa, Tatsuo Takeya

Affiliation

¹ Graduate School of Materials Science, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, 630-0192, Japan. aikeda@ms.naist.jp

PMID: 19277385
DOI: 10.1039/b820768b

Abstract

[70]Fullerene (C70) was directly incorporated into the cell membrane using an exchange reaction from a C70-gamma-cyclodextrin (gamma-CDx) complex within 10 min and the incorporated C70 acted as a photodynamic sensitiser for a cancer cell.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Absorption
Cell Membrane / physiology*
Fullerenes / chemistry*
Fullerenes / pharmacokinetics
HeLa Cells
Humans
Macromolecular Substances / chemistry
Models, Biological*
Photosensitizing Agents / chemistry*
Spectrophotometry
gamma-Cyclodextrins / chemistry*

Substances

Fullerenes
Macromolecular Substances
Photosensitizing Agents
gamma-Cyclodextrins
fullerene C70
gamma-cyclodextrin