Evidence of dissociated arousal states during NREM parasomnia from an intracerebral neurophysiological study

Sleep. 2009 Mar;32(3):409-12. doi: 10.1093/sleep/32.3.409.

Abstract

Study objectives: Arousal parasomnias are expressions of sleep/ wake state dissociations in which wakefulness and NREM sleep seem to coexist. We describe the results of a neurophysiological (intracerebral EEG) investigation that captured an episode of confusional arousal.

Design: Observational analysis.

Setting: Tertiary sleep center.

Subject: A 20-year-old male with refractory focal epilepsy.

Measurements and results: The intracerebral EEG findings documented the presence of a local arousal of the motor and cingulate cortices associated with increased delta activity in the frontoparietal associative cortices; these findings were noted preceding the onset and persisting throughout the episode.

Conclusions: The presence of dissociated sleep/wake states in confusional arousals is the expression not of a global phenomenon, but rather of the coexistence of different local states of being: arousal of the motor and cingulate cortices and inhibition of the associative ones. Whether this is an exclusive feature of NREM parasomnias, or a common substrate on which other triggering elements act, needs to be clarified.

Publication types

  • Case Reports

MeSH terms

  • Arousal / physiology*
  • Brain Mapping
  • Cerebral Cortex / physiopathology*
  • Dissociative Disorders / physiopathology*
  • Dominance, Cerebral / physiology
  • Electroencephalography*
  • Epilepsies, Partial / physiopathology*
  • Epilepsies, Partial / surgery
  • Frontal Lobe / physiopathology
  • Gyrus Cinguli / physiopathology
  • Humans
  • Male
  • Motor Cortex / physiopathology
  • Nerve Net / physiopathology
  • Parasomnias / physiopathology*
  • Parietal Lobe / physiopathology
  • Signal Processing, Computer-Assisted*
  • Sleep Stages / physiology*
  • Somnambulism / physiopathology
  • Video Recording
  • Young Adult