Lung transplantation: does oxidative stress contribute to the development of bronchiolitis obliterans syndrome?

Janet Madill; Ellie Aghdassi; Bianca Arendt; Brenda Hartman-Craven; Carlos Gutierrez; Chung-Wai Chow; Johane Allard; University Health Network

doi:10.1016/j.trre.2009.01.003

Lung transplantation: does oxidative stress contribute to the development of bronchiolitis obliterans syndrome?

Transplant Rev (Orlando). 2009 Apr;23(2):103-10. doi: 10.1016/j.trre.2009.01.003.

Authors

Janet Madill¹, Ellie Aghdassi, Bianca Arendt, Brenda Hartman-Craven, Carlos Gutierrez, Chung-Wai Chow, Johane Allard; University Health Network

Affiliation

¹ University of Toronto, Lung Transplant Program, University Health Network, Toronto, ON, Canada.

PMID: 19298941
DOI: 10.1016/j.trre.2009.01.003

Abstract

Lung transplantation is the ultimate treatment of end-stage lung disease. After transplantation, the 1-year survival rate is 80%. However, 5-year survival rates drop to 50% due to bronchiolitis obliterans syndrome (BOS). Ischemia/reperfusion injury, infections, and acute rejection are major risk factors contributing to the development of BOS. These risk factors are also associated with increased oxidative stress. Oxidative stress is a condition whereby prooxidants overwhelm the antioxidant defense system and may contribute to the pathogenesis of BOS by inducing more tissue injury and inflammation. This article reviews the current state of knowledge on oxidative stress in lung transplantation and BOS.

Publication types

Review

MeSH terms

Bronchiolitis Obliterans / etiology*
Bronchiolitis Obliterans / metabolism*
Bronchiolitis Obliterans / mortality
Humans
Lung Transplantation* / mortality
Oxidative Stress / physiology*
Postoperative Complications / etiology
Postoperative Complications / metabolism
Postoperative Complications / mortality
Risk Factors