Palladium-catalyzed oxidative intermolecular difunctionalization of terminal alkenes with organostannanes and molecular oxygen

Angew Chem Int Ed Engl. 2009;48(17):3146-9. doi: 10.1002/anie.200900218.

Abstract

A cationic palladium complex catalyzes the title transformations, which are thought to proceed via a pi-allyl or pi-benzyl intermediate. The regioselectivity of the reaction (1,2- or 1,1-difunctionalization) depends on the type of terminal double bond (conjugated or nonconjugated) in the substrate (see scheme) and appears to be controlled by the relative rates of beta-hydride elimination and transmetalation. DMA=dimethylacetamide, Tf=triflyl.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkenes / chemistry*
  • Catalysis
  • Organotin Compounds / chemistry*
  • Oxidation-Reduction
  • Oxygen / chemistry*
  • Palladium / chemistry*

Substances

  • Alkenes
  • Organotin Compounds
  • Palladium
  • Oxygen