Migraine is a multifactorial and heterogeneous disorder. Diagnostic criteria have been established by the International Headache Society, however these are only supportive in terms of definition. The pathophysiology involves neuronal and vascular phenomena. The former is supported by the cortical spreading depression being the aura correlate and by brainstem and hypothalamic activation during the pain phase; the latter is suggested by the association between migraine and cardiovascular disease and findings of pathological vasoreactivity and endothelial dysfunction. Triptans and calcitonin gene-related peptide receptor antagonists show only a relative migraine-specific action; up to 30% of patients are nonresponders. Despite a clear genetic component, the discovery of specific genes for common forms of migraine remains elusive. Electrophysiological studies consistently indicate a characteristic "dyshabituation" concurring with clinical features of altered sensory perception. The age- and sex-specific pattern along with the effect of external factors on the course of migraine argue in favor of the involvement of epigenetic mechanisms. Knowledge about migraine is still limited, which hampers a definition.