Rapid and secure tissue adherence using adhesives or sealants is an attractive concept. Cyanoacrylates, marine adhesive proteins, fibrin-based sealants, and mixtures of polypeptides and proteoglycans to form "laser solders" are just some of the products and technologies that have been used. Effectiveness, ease of use, cost, strength, degradation, safety, and toxicity are major concerns in seeking an ideal product. Thomas A. Mustoe, MD; Gordon H. Sasaki, MD; and Renato Saltz, MD, address some commonly asked questions about the clinical use of tissue adhesives and sealants in response to questions posed by "Comparing Notes" editor, Alan H. Gold, MD. (Aesthetic Surg J 2003;23:500-503.).