Researchers have identified sources of technology-induced errors involving health information systems (HIS) across the software development lifecycle. In this paper the authors review approaches to identifying technology-induced error and describe, compare and contrast the advantages and disadvantages of using predictive and post-implementation methodologies to identify technology-induced error. Following this, the authors focus upon clinical simulations using scenario-based testing as a methodology for diagnosing technology-induced errors to assess HIS ability to respond to the stresses and strains of health professionals using such systems in real-world clinical settings.