Predicting health-related quality of life of parents of children with inherited metabolic diseases

Acta Paediatr. 2009 Jul;98(7):1205-10. doi: 10.1111/j.1651-2227.2009.01269.x. Epub 2009 Apr 21.

Abstract

Aim: The aim of this study was to examine medical, socio-demographic and psychosocial determinants of health-related quality of life (HRQoL) of parents of children with metabolic diseases.

Methods: A survey among parents of children with metabolic diseases (children aged 1-19 years, diagnosed >1 year before the start of the study, living at home). Parents were approached through the Emma Children's Hospital, and through a national parent and patient association. HRQoL was assessed using the TNO-AZL Questionnaire for Adult's Health Related Quality of Life (TAAQOL), describing 12 domains of HRQoL. Predictor variables were taken from a self-report questionnaire. Univariate and multivariate logistic regression analyses were performed to predict which parents were at risk for HRQoL impairment.

Results: Mainly psychosocial determinants were predictive for parental HRQoL. Emotional support was protective for parental HRQOL while loss of friendship was a risk factor for HRQoL impairment. Medical and socio-demographic variables did not consistently predict parental HRQoL.

Conclusion: Psychosocial determinants appeared more important in predicting parental HRQoL than medical and socio-demographic variables. Interventions should be focused on supporting parents combining the care for their children with a social life. Further research on this subject is necessary. In the meantime, involved medical specialists should pay structural attention to parental functioning.

MeSH terms

  • Adaptation, Psychological
  • Adolescent
  • Adult
  • Caregivers / psychology*
  • Chi-Square Distribution
  • Child
  • Child, Preschool
  • Cross-Sectional Studies
  • Health Status
  • Humans
  • Infant
  • Logistic Models
  • Metabolism, Inborn Errors* / genetics
  • Mitochondrial Diseases / genetics
  • Multivariate Analysis
  • Parents / psychology*
  • Psychometrics
  • Quality of Life*
  • Surveys and Questionnaires
  • Young Adult