Abstract
The first carbon monoxide-releasing molecules (CO-RMs) based on mu2-alkyne dicobalt(0)hexacarbonyl complexes are reported. The alkyne substituents significantly affect the rate of CO-release, cytotoxicity and cell viability. Mechanistic studies provide insight into the CO-RM activation pathways.
MeSH terms
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Alkynes / chemistry*
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Animals
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Carbon Monoxide / chemistry
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Carbon Monoxide / metabolism*
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Cell Survival / drug effects
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Cobalt / chemistry*
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Drug Carriers / chemistry*
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Drug Carriers / toxicity
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Organometallic Compounds / chemistry*
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Organometallic Compounds / toxicity
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Temperature
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Time Factors
Substances
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Alkynes
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Drug Carriers
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Organometallic Compounds
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Cobalt
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Carbon Monoxide