Abstract
Treating African trypanosomiasis: The synthesis and biological evaluation of novel 1-alkyloxy and 1-benzyloxyadamantano 2-guanylhydrazones, their 1-dioxa congeners and two 1-benzyladamantano 2-guanylhydrazones is reported. Preliminary structure-activity relationship data were elucidated and lead compounds suitable for further optimization were discovered.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Drug Design
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Hydrazones / chemical synthesis*
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Hydrazones / chemistry
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Hydrazones / pharmacology
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Parasitic Sensitivity Tests
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Structure-Activity Relationship
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Trypanocidal Agents / chemical synthesis*
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Trypanocidal Agents / chemistry
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Trypanocidal Agents / pharmacology
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Trypanosoma brucei brucei / drug effects*
Substances
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Hydrazones
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Trypanocidal Agents