Combining 2-deoxy-D-glucose with electron transport chain blockers: a double-edged sword

Cancer Biol Ther. 2009 Jul;8(13):1237-8. doi: 10.4161/cbt.8.13.8869. Epub 2009 Jul 29.
No abstract available

Publication types

  • Comment
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Antimycin A / pharmacology
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Cell Survival / drug effects
  • Colonic Neoplasms / drug therapy*
  • Colonic Neoplasms / metabolism
  • Colonic Neoplasms / pathology
  • Deoxyglucose / administration & dosage
  • Deoxyglucose / pharmacology*
  • Drug Synergism
  • Electron Transport / drug effects
  • Glutathione / metabolism
  • Glutathione Disulfide / metabolism
  • HCT116 Cells
  • HT29 Cells
  • Humans
  • Mice
  • Mice, Nude
  • Mitochondria / drug effects
  • Mitochondria / metabolism
  • Oxidation-Reduction / drug effects
  • Oxidative Stress / drug effects*
  • Rotenone / administration & dosage
  • Rotenone / pharmacology*
  • Tumor Burden / drug effects
  • Uncoupling Agents / administration & dosage
  • Uncoupling Agents / pharmacology
  • Xenograft Model Antitumor Assays

Substances

  • Uncoupling Agents
  • Rotenone
  • Antimycin A
  • Deoxyglucose
  • Glutathione
  • Glutathione Disulfide