Dexamethasone decreases the transmesothelial electrical resistance of the parietal and visceral pleura

Sotirios Zarogiannis; Triantafyllia Deligiorgi; Ioannis Stefanidis; Vassilios Liakopoulos; Konstantinos Gourgoulianis; Paschalis Adam Molyvdas; Chrissi Hatzoglou

doi:10.1007/s12576-009-0042-x

Dexamethasone decreases the transmesothelial electrical resistance of the parietal and visceral pleura

J Physiol Sci. 2009 Jul;59(4):335-9. doi: 10.1007/s12576-009-0042-x. Epub 2009 May 22.

Authors

Sotirios Zarogiannis¹, Triantafyllia Deligiorgi, Ioannis Stefanidis, Vassilios Liakopoulos, Konstantinos Gourgoulianis, Paschalis Adam Molyvdas, Chrissi Hatzoglou

Affiliation

¹ Department of Physiology, University of Thessaly Medical School, Mezourlo Hill, 41110 Larissa, Greece.

Abstract

The effect of dexamethasone on the transmesothelial electrical resistance (R(TM)) of sheep pleura was investigated by Ussing chamber experiments. Our results show that dexamethasone decreases the R(TM) of sheep pleurae, in part by stimulation of glucocorticoid receptors. This finding may be of importance in regard to the faster resolution of corticosteroid-treated pleural effusions.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Dexamethasone / pharmacology*
Electric Impedance
Epithelium / drug effects
Epithelium / physiology
Female
Glucocorticoids / pharmacology
In Vitro Techniques
Male
Pleura / drug effects*
Pleura / physiology*
Pleural Effusion / drug therapy
Receptors, Glucocorticoid / drug effects
Receptors, Glucocorticoid / physiology
Sheep

Substances

Glucocorticoids
Receptors, Glucocorticoid
Dexamethasone