Matrix metalloproteinase-2 gene variants and abdominal aortic aneurysm

Eur J Vasc Endovasc Surg. 2009 Aug;38(2):169-71. doi: 10.1016/j.ejvs.2009.04.019. Epub 2009 Jun 10.

Abstract

Objective: To investigate associations between two polymorphisms of the matrix metalloproteinase-2 gene (MMP2) and the incidence and progression of abdominal aortic aneurysm (AAA).

Methods: Cases and controls were recruited from a trial of screening for AAAs. The association between two variants of MMP2 (-1360C>T, and +649C>T) in men with AAA (n=678) and in controls (n=659) was examined using multivariate analyses. The association with AAA expansion (n=638) was also assessed.

Results: In multivariate analyses with adjustments for multiple testing, no association between either SNP and AAA presence or expansion was detected.

Conclusion: MMP2 -1360C>T and +649C>T variants are not risk factors for AAA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aortic Aneurysm, Abdominal / enzymology
  • Aortic Aneurysm, Abdominal / epidemiology
  • Aortic Aneurysm, Abdominal / genetics*
  • Case-Control Studies
  • Disease Progression
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Humans
  • Incidence
  • Logistic Models
  • Male
  • Mass Screening
  • Matrix Metalloproteinase 2 / genetics*
  • Odds Ratio
  • Phenotype
  • Polymorphism, Single Nucleotide*
  • Risk Assessment
  • Risk Factors
  • Western Australia / epidemiology

Substances

  • MMP2 protein, human
  • Matrix Metalloproteinase 2