Abstract
Reprogramming of mouse and human somatic cells into induced pluripotent stem (iPS) cells has been made possible with the expression of the transcription factor quartet Oct4, Sox2, c-Myc, and Klf4. Here, we compared iPS cells derived from mouse embryonic fibroblasts with the 4 factors to embryonic stem cells by electron microscopy. Both cell types are almost indistinguishable at the ultrastructural level, providing further evidence for the similarity of these 2 pluripotent stem cell populations.
MeSH terms
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Animals
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Cells, Cultured
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Cellular Reprogramming / drug effects*
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Embryonic Stem Cells / cytology
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Fibroblasts / cytology
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Induced Pluripotent Stem Cells / cytology*
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Kruppel-Like Factor 4
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Kruppel-Like Transcription Factors / pharmacology
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Mice
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Microscopy, Electron
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Octamer Transcription Factor-3 / pharmacology
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Proto-Oncogene Proteins c-myc / pharmacology
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SOXB1 Transcription Factors / pharmacology
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Transcription Factors / pharmacology*
Substances
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KLF4 protein, human
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Klf4 protein, mouse
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Kruppel-Like Factor 4
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Kruppel-Like Transcription Factors
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Myc protein, mouse
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Octamer Transcription Factor-3
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Pou5f1 protein, mouse
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Proto-Oncogene Proteins c-myc
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SOXB1 Transcription Factors
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Sox2 protein, mouse
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Transcription Factors