A multicenter study on optimizing piperacillin-tazobactam use: lessons on why interventions fail

Infect Control Hosp Epidemiol. 2009 Aug;30(8):794-6. doi: 10.1086/599002.

Abstract

We examined interventions to optimize piperacillin-tazobactam use at 4 hospitals. Interventions for rotating house staff did not affect use. We could target empiric therapy in only 35% of cases. Because prescribing practices seemed to be institution specific, interventions should address attitudes of local prescribers. Interventions should target empiric therapy and ordering of appropriate cultures.

Publication types

  • Multicenter Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Anti-Bacterial Agents / therapeutic use*
  • Colony Count, Microbial
  • Drug Resistance, Bacterial
  • Drug Utilization / statistics & numerical data
  • Focus Groups
  • Health Knowledge, Attitudes, Practice
  • Hospitals, University
  • Hospitals, Veterans
  • Humans
  • Microbial Sensitivity Tests
  • Penicillanic Acid / analogs & derivatives
  • Penicillanic Acid / therapeutic use
  • Piperacillin / therapeutic use
  • Piperacillin, Tazobactam Drug Combination
  • Practice Patterns, Physicians'*

Substances

  • Anti-Bacterial Agents
  • Piperacillin, Tazobactam Drug Combination
  • Penicillanic Acid
  • Piperacillin