Background: Multilocular cystic renal cell carcinoma is an uncommon variant recently described of renal cell carcinoma.
Aim: Analyze clinicopathological features, imaging findings and prognosis and therapeutic options of this tumor.
Case reports: The authors reported two cases of multilocular cystic renal cell carcinoma arising in 68 and 39-year-old men. They were admitted with pain in the lumbar region and/or haematuria. The imaging findings were a renal neoplasm with cystic and solid areas. The pathologic findings confirm the diagnosis of multilocular cystic renal cell carcinoma.
Conclusion: Multilocular cystic renal cell carcinoma, usually identified at earlier stages, had slower growth rate and was therefore associated with a better prognosis and longer survival than conventional renal cell carcinoma.