[An azidomethyl protective group in the synthesis of oligoribonucleotides by the phosphotriester method]

Bioorg Khim. 2009 Mar-Apr;35(2):270-3. doi: 10.1134/s1068162009020149.
[Article in Russian]

Abstract

A rapid and effective method of an automatic oligoribonucleotide synthesis alternative to the phosphoroamidite one was developed based on the phosphotriester approach of internucleotide bond formation under intramolecular O-nucleophilic catalysis and the use of an azidomethyl group for protection of a nucleotide 2'-hydroxyl function.

Publication types

  • English Abstract
  • Letter

MeSH terms

  • Catalysis
  • Oligoribonucleotides / chemical synthesis*
  • Oligoribonucleotides / chemistry*

Substances

  • Oligoribonucleotides