CALHM1 variant is not associated with Alzheimer's disease among Asians

Neurobiol Aging. 2011 Mar;32(3):546.e11-2. doi: 10.1016/j.neurobiolaging.2009.05.008. Epub 2009 Jul 9.

Abstract

In a case control study involving 484 study subjects, we showed that the CALHM1 allele (13.5% vs 16.7%) and genotype frequency was not significantly different between Alzheimer's disease (AD) and controls. Logistic regression analysis did not reveal any interaction between ApoE4 allele and CALHM1 allele.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / genetics*
  • Apolipoprotein E4 / genetics
  • Asia / epidemiology
  • Asia / ethnology
  • Calcium Channels / genetics*
  • Case-Control Studies
  • Female
  • Gene Frequency
  • Genome-Wide Association Study / methods
  • Genotype
  • Humans
  • Logistic Models
  • Male
  • Membrane Glycoproteins / genetics*
  • Middle Aged
  • Polymorphism, Single Nucleotide / genetics*

Substances

  • Apolipoprotein E4
  • CALHM1 protein, human
  • Calcium Channels
  • Membrane Glycoproteins