Reflections on miR-ing effects in metastasis

Nancy Dumont; Thea D Tlsty

doi:10.1016/j.ccr.2009.06.013

Reflections on miR-ing effects in metastasis

Cancer Cell. 2009 Jul 7;16(1):3-4. doi: 10.1016/j.ccr.2009.06.013.

Authors

Nancy Dumont¹, Thea D Tlsty

Affiliation

¹ Department of Pathology, University of California at San Francisco, San Francisco, CA 94143, USA.

PMID: 19573805
DOI: 10.1016/j.ccr.2009.06.013

Abstract

In a recent issue of Cell, Valastyan et al. demonstrate that miR-31 can regulate multiple steps in the metastatic cascade independent of confounding effects on primary tumor development. These data have potential to provide biomarkers for prognosis and novel targets for intervention in this most lethal aspect of malignancy.

Publication types

Comment

MeSH terms

Animals
Bone Marrow / pathology
Breast / physiology
Breast Neoplasms / genetics*
Breast Neoplasms / mortality
Breast Neoplasms / pathology
Cell Line, Tumor
Female
Humans
Mice
MicroRNAs / genetics*
Neoplasm Metastasis / genetics*
Survival Analysis

Substances

MIRN31 microRNA, human
MicroRNAs