Preparation, characterization and dissolution studies of fast release diclofenac sodium tablets from PVP solid dispersions

Pharm Dev Technol. 2010 Mar-Apr;15(2):162-8. doi: 10.1080/10837450903085400.

Abstract

Diclofenac sodium is a non-steroidal anti-inflammatory drug widely used in the treatment of ankylosing spondylitis, rheumatoid arthritis and osteoarthritis. In this context, a rapid onset of action is required. Thus, the aim of this study was to formulate diclofenac sodium-PVP K-30 fast release tablets from solid dispersions. The physical state and drug:carrier interactions were analyzed by X-ray diffraction and scanning electron microscopy and stability upon storage was also studied. Dissolution rate of diclofenac sodium from solid dispersions was markedly enhanced by increasing the polymer concentration.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / administration & dosage*
  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Diclofenac / administration & dosage*
  • Diclofenac / chemistry
  • Drug Carriers / chemistry*
  • Drug Stability
  • Drug Storage
  • Povidone / chemistry*
  • Solubility
  • Tablets
  • Time Factors

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Drug Carriers
  • Tablets
  • Diclofenac
  • Povidone