Abstract
The condensation of 7-amino-4-methyl-coumarin (1) with a number of substituted salicylaldehydes yielded a series of Schiff bases (2a-2k) in good yields. Subsequent reaction of these ligands with copper(II) acetate yielded Cu(II) complexes (3a-3k) and some were characterised using X-ray crystallography. All of the free ligands and their metal complexes were tested for their anti-Candida activity. A number of the ligands and complexes exhibited anti-Candida activity comparable to that of the commercially available antifungal drugs, ketoconazole and Amphotericin B.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aldehydes / chemistry*
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Antifungal Agents / chemistry*
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Antifungal Agents / pharmacology
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Candida albicans / drug effects*
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Chelating Agents / chemical synthesis
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Chelating Agents / chemistry*
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Chelating Agents / pharmacology
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Copper / chemistry*
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Coumarins / chemistry*
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Crystallography, X-Ray
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Drug Design
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Ligands
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Models, Molecular
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Molecular Structure
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Organometallic Compounds / chemical synthesis
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Organometallic Compounds / chemistry*
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Organometallic Compounds / toxicity
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Schiff Bases / chemical synthesis
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Schiff Bases / chemistry
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Schiff Bases / pharmacology
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Spectrophotometry
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Transition Temperature
Substances
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Aldehydes
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Antifungal Agents
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Chelating Agents
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Coumarins
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Ligands
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Organometallic Compounds
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Schiff Bases
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Copper
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7-amino-4-methylcoumarin