Abstract
Animal models for HIV research have been indispensible in fulfilling Koch's postulate and in exploring issues of viral infectivity and pathogenesis, sequence divergence, route(s) of acquisition, tissue distribution and tropism, immunogenicity and protection capacity of vaccine candidates, escape from adaptive immunity, and more. Did they fail to predict the efficacy of T-cell vaccines in humans? This article summarizes progress and status of models to inform and complement clinical work.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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AIDS Vaccines / immunology
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Acquired Immunodeficiency Syndrome / drug therapy*
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Acquired Immunodeficiency Syndrome / immunology
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Acquired Immunodeficiency Syndrome / virology
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Animals
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Antiretroviral Therapy, Highly Active
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Antiviral Agents / therapeutic use*
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Biomedical Research / methods
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Biomedical Research / trends
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Disease Models, Animal*
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HIV-1 / drug effects*
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HIV-1 / immunology
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Humans
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Macaca / immunology
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Macaca / virology
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Simian Acquired Immunodeficiency Syndrome / drug therapy
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Simian Acquired Immunodeficiency Syndrome / immunology
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Simian Acquired Immunodeficiency Syndrome / virology
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Simian Immunodeficiency Virus / drug effects
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Simian Immunodeficiency Virus / immunology
Substances
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AIDS Vaccines
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Antiviral Agents