Urgent need in methodology of information estimation for true clinical decision taking gave powerful impulse for evidence based medicine concept development that appeared at the end of 80th years. Proved efficacy and safety, optimal correlation of the indices were the stages of the methods and means selection for rationing. In our country such approach found its reflection in developing clinical protocol conducting (standards for doctors), in vitaly important medicines listing and lists of medicines that could be refunded in the system of additional medicine provision.