Intrusive HIV-1-infected cells

Dominika Rudnicka; Olivier Schwartz

doi:10.1038/ni0909-933

Intrusive HIV-1-infected cells

Nat Immunol. 2009 Sep;10(9):933-4. doi: 10.1038/ni0909-933.

Authors

Dominika Rudnicka, Olivier Schwartz

PMID: 19692990
DOI: 10.1038/ni0909-933

Abstract

Macrophages infected with human immunodeficiency virus type 1 emit long intercellular conduits that shuttle the viral protein Nef to bystander B cells, where it impairs cellular function and immunoglobulin class switching.

Publication types

News

MeSH terms

B-Lymphocytes / immunology*
HIV-1 / physiology*
Humans
Immunoglobulin Class Switching*
Macrophages / virology*
nef Gene Products, Human Immunodeficiency Virus / physiology*

Substances

nef Gene Products, Human Immunodeficiency Virus
nef protein, Human immunodeficiency virus 1