Study of the parental origin of sexual aneuploidy in ten families using RFLPs

M Villamar; E Fernandez; C Ayuso; C Ramos; J Benitez

Study of the parental origin of sexual aneuploidy in ten families using RFLPs

Ann Genet. 1990;33(1):29-31.

Authors

M Villamar¹, E Fernandez, C Ayuso, C Ramos, J Benitez

Affiliation

¹ Departemento de Genética, Fundación Jiménez Diaz, Madrid, Spain.

PMID: 1973343

Abstract

We have studied 10 families with sexual aneuploidy by means of recombinant DNA techniques. The X linked probes were F814 (DXS52), FIX (FVIII gene), pert 87.15 (DXS164), L754 (DXS84) and 47Z (DXYS5). The observed banding patterns allowed us to determine the parental origin of such aneuploidy in nine of our cases. It was paternal in seven cases and maternal in two.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cells, Cultured
Chromosome Banding
DNA Probes
Female
Humans
Lymphocytes / ultrastructure
Nondisjunction, Genetic*
Polymorphism, Restriction Fragment Length*
Pregnancy
Prenatal Diagnosis
Sex Chromosome Aberrations / diagnosis
Sex Chromosome Aberrations / genetics
Trisomy
Turner Syndrome / genetics*
X Chromosome*

Substances

DNA Probes