Abstract
Murine intraepithelial lymphocytes (IEL) consist of two main populations. Approximately half are Thy-1+, most of which are CD3+, T cell receptor (TcR) alpha/beta+, and the remainder are Thy-1-, most of which are CD3+, TcR alpha/beta- (presumably TcR gamma/delta+). In redirected cytotoxicity assays, TcR alpha/beta+ IEL are potent cytotoxic effectors. Thy-1-, CD3+, TcR alpha/beta- IEL isolated from athymic mice are also cytotoxic. Thus, regardless of TcR usage or Thy-1 expression, IEL are cytotoxic effectors.
MeSH terms
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Animals
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Antigens, Differentiation, T-Lymphocyte / analysis
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Antigens, Surface / analysis
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CD3 Complex
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Flow Cytometry
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Intestinal Mucosa / immunology*
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Mice
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Mice, Inbred BALB C
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Mice, Nude
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Receptors, Antigen, T-Cell / analysis
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Receptors, Antigen, T-Cell, alpha-beta
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Receptors, Antigen, T-Cell, gamma-delta
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T-Lymphocytes, Cytotoxic / immunology*
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Thy-1 Antigens
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Thymus Gland / physiology
Substances
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Antigens, Differentiation, T-Lymphocyte
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Antigens, Surface
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CD3 Complex
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Receptors, Antigen, T-Cell
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Receptors, Antigen, T-Cell, alpha-beta
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Receptors, Antigen, T-Cell, gamma-delta
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Thy-1 Antigens