GOLPH2 gene markers are not associated with Alzheimer's disease in a sample of the Spanish population

J Alzheimers Dis. 2009;18(4):751-4. doi: 10.3233/JAD-2009-1200.

Abstract

GOLPH2 gene SNP variants Rs10868366 and Rs7019241 were reported to decrease the risk of Alzheimer's disease in a recent Whole Genome Association Study. We have investigated these genetic variants in 2470 individuals from Spain to conduct an independent replication study of the proposed SNP markers. We found no evidence of association between GOLPH2 markers and susceptibility to Alzheimer's disease in our series. We concluded that GOLPH2 gene does not contribute to risk of disease in this study sample.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Aging / genetics
  • Alzheimer Disease / epidemiology
  • Alzheimer Disease / genetics*
  • Apolipoproteins E / metabolism
  • Chromosomes, Human, Pair 19
  • Female
  • Genetic Markers
  • Genetic Predisposition to Disease*
  • Genetic Testing
  • Genome, Human
  • Genome-Wide Association Study
  • Genotype
  • Humans
  • Male
  • Membrane Proteins / genetics*
  • Membrane Proteins / metabolism*
  • Polymorphism, Single Nucleotide
  • Risk Factors
  • Spain

Substances

  • Apolipoproteins E
  • GOLM1 protein, human
  • Genetic Markers
  • Membrane Proteins