The acquisition during development of Ca-activated potassium currents by cochlear hair cells of the chick

Proc Biol Sci. 1990 Aug 22;241(1301):122-6. doi: 10.1098/rspb.1990.0075.

Abstract

Voltage-clamp recordings were done on hair cells from a region of the chick's cochlea. In the adult, these cells have voltage-sensitive Ca currents and rapid, Ca-activated K currents that together support an electrical resonance, showing voltage oscillations at frequencies greater than 100 Hz. In embryos 14-days old (at one week before hatching) the same cells had a voltage-sensitive Ca current like that in adults, but a more slowly acting K current (of the delayed-rectifier type). In current-clamp they could generate only slowly repetitive action potentials. By two days before hatching, Ca-activated K currents were present. We suggest that the acquisition of Ca-activated K currents contributes to functional maturation of the chick's cochlea.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Action Potentials / drug effects
  • Animals
  • Calcium / pharmacology*
  • Cell Membrane / physiology
  • Cesium / pharmacology
  • Chick Embryo
  • Chickens
  • Chlorides*
  • Hair Cells, Auditory / drug effects
  • Hair Cells, Auditory / embryology
  • Hair Cells, Auditory / physiology*
  • In Vitro Techniques
  • Membrane Potentials
  • Potassium Channels / drug effects
  • Potassium Channels / physiology*
  • Time Factors

Substances

  • Chlorides
  • Potassium Channels
  • Cesium
  • cesium chloride
  • Calcium