Abstract
We compared a lateral flow device to galactomannan and (1-->3)-beta-D-glucan assays to detect invasive aspergillosis in an established guinea pig model of pulmonary disease. The lateral flow device became positive earlier (day 3) than the (1-->3)-beta-D-glucan and galactomannan assays (day 5), with all samples positive by each assay on day 7.
Publication types
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Comparative Study
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antigens, Fungal / analysis*
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Antigens, Fungal / immunology
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Aspergillus / immunology
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Aspergillus / isolation & purification*
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Biomarkers / analysis
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Chromatography, Liquid / instrumentation
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Galactose / analogs & derivatives
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Guinea Pigs
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Immunoassay / instrumentation
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Invasive Pulmonary Aspergillosis / diagnosis*
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Invasive Pulmonary Aspergillosis / immunology
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Male
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Mannans / analysis*
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Mannans / immunology
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Point-of-Care Systems
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Proteoglycans
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Sensitivity and Specificity
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beta-Glucans / analysis*
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beta-Glucans / immunology
Substances
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Antigens, Fungal
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Biomarkers
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Mannans
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Proteoglycans
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beta-Glucans
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galactomannan
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polysaccharide-K
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Galactose