Effect of treatment with losartan on salt sensitivity and SGLT2 expression in hypertensive diabetic rats

Diabetes Res Clin Pract. 2009 Dec;86(3):e46-9. doi: 10.1016/j.diabres.2009.09.006. Epub 2009 Oct 2.

Abstract

Sodium-glucose cotransporters (SGLTs) in the kidney, may be involved in hypertension, diabetes and salt sensitivity. We evaluate the effect of losartan on blood pressure (BP) and SGLT2 expression in diabetic rats with high or normal salt diet. Losartan prevented an increase in BP and SGLT2 expression in diabetic rats.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antihypertensive Agents / therapeutic use
  • Blood Pressure
  • Diabetes Complications / drug therapy*
  • Diabetes Mellitus, Experimental / complications
  • Diabetes Mellitus, Experimental / genetics*
  • Diabetes Mellitus, Experimental / pathology
  • Diabetes Mellitus, Experimental / physiopathology
  • Diuresis
  • Gene Expression Regulation
  • Glomerular Filtration Rate
  • Hypertension / complications
  • Hypertension / drug therapy*
  • Hypertension / genetics
  • Hypertension / physiopathology
  • Kidney Cortex / pathology
  • Losartan / therapeutic use*
  • Male
  • Rats
  • Rats, Wistar
  • Receptor, Angiotensin, Type 1 / drug effects
  • Receptor, Angiotensin, Type 1 / physiology
  • Sodium, Dietary
  • Sodium-Glucose Transporter 2 / genetics*

Substances

  • Antihypertensive Agents
  • Receptor, Angiotensin, Type 1
  • Slc5a2 protein, rat
  • Sodium, Dietary
  • Sodium-Glucose Transporter 2
  • Losartan