Prospective, longitudinal data from a community sample of 451 families were used to assess the unique contribution of paternal depressive symptoms to adolescent functioning. Results indicated that paternal depressive symptoms were significantly related to subsequent depressive symptoms in adolescent offspring; this association remained significant after controlling for previous adolescent depressive symptoms, maternal depressive symptoms, gender, and family demographic variables. Adolescent gender and perception of father-adolescent relationship closeness moderated this association such that paternal depressive symptoms were positively associated with adolescent depressive symptoms for girls whose relations with fathers lacked closeness. These findings add to a growing literature on the interpersonal mechanisms through which depression runs in families, highlighting the need for future investigation of paternal mental health, adolescent gender, and intrafamily relationship quality in relation to adolescent development.