Abstract
RipA is an important growth factor of M. tuberculosis. Its depletion produces decreasing bacterial growth and an abnormal phenotype. RipA C-terminal fragment (263-472), containing its predicted catalytic domain has been successfully crystallized using vapor-diffusion methods. The structure has been solved by Multiwavelength Anomalous Dispersion and atomic resolution refinement is in progress.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bacterial Proteins / biosynthesis
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Bacterial Proteins / chemistry*
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Bacterial Proteins / genetics
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Bacterial Proteins / isolation & purification
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Crystallography, X-Ray
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Cytokines / biosynthesis
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Cytokines / chemistry*
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Cytokines / genetics
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Cytokines / isolation & purification
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Escherichia coli / genetics
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Mycobacterium tuberculosis / chemistry*
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Mycobacterium tuberculosis / genetics
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Mycobacterium tuberculosis / metabolism
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Protein Conformation
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Recombinant Proteins / biosynthesis
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Recombinant Proteins / chemistry*
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Recombinant Proteins / genetics
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Recombinant Proteins / isolation & purification
Substances
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Bacterial Proteins
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Cytokines
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Recombinant Proteins
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resuscitation-promoting factor, bacteria