Acute myocardial infarction due to vasospasm induced by prostaglandin

Can J Cardiol. 2009 Oct;25(10):e359-60. doi: 10.1016/s0828-282x(09)70724-x.

Abstract

Prostaglandin E (PGE) is the preferred agent for second-trimester pregnancy termination. Hypotension, bradycardia, ventricular arrhythmias, myocardial infarction, cardiac arrest and death associated with PGE have been reported. A case of acute myocardial infarction due to coronary vasospasm induced by PGE is described in the present report. The diagnosis was confirmed by electrocardiography and coronary angiography.

La prostaglandine E (PGE) est l’agent favorisé en cas d’interruption de grossesse du deuxième trimestre. On a déclaré des cas d’hypotension, de bradycardie, d’arythmies ventriculaires, d’infarctus du myocarde, d’arrêt cardiaque et de décès associés à la PGE. Le présent rapport expose un cas d’infarctus aigu du myocarde causé par un vasospasme coronaire induit par la PGE. L’électrocardiographie et la coronarographie ont confirmé le diagnostic.

Publication types

  • Case Reports

MeSH terms

  • Administration, Intravaginal
  • Adult
  • Alprostadil / administration & dosage
  • Alprostadil / adverse effects*
  • Coronary Angiography
  • Coronary Vasospasm / chemically induced*
  • Coronary Vasospasm / complications
  • Coronary Vasospasm / diagnosis
  • Electrocardiography
  • Female
  • Humans
  • Myocardial Infarction / diagnosis
  • Myocardial Infarction / etiology*
  • Myocardial Infarction / physiopathology
  • Pregnancy
  • Pregnancy Complications, Cardiovascular*
  • Pregnancy Outcome
  • Vasodilator Agents / administration & dosage
  • Vasodilator Agents / adverse effects

Substances

  • Vasodilator Agents
  • Alprostadil