Immunological and biochemical correlates of adjunctive dexamethasone in Vietnamese adults with bacterial meningitis

Clin Infect Dis. 2009 Nov 1;49(9):1387-92. doi: 10.1086/630207.

Abstract

Adjunctive treatment to improve outcome from bacterial meningitis has centered on dexamethasone. Among Vietnamese patients with bacterial meningitis, cerebrospinal fluid (CSF) opening pressure and CSF:plasma glucose ratios were significantly improved and levels of CSF cytokines interleukin (IL)-6, IL-8, and IL-10 and were all statistically significantly lower after treatment in patients who were randomized to dexamethasone, compared with levels in patients who received placebo.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Anti-Inflammatory Agents / therapeutic use
  • Asian People
  • Child
  • Dexamethasone / therapeutic use*
  • Female
  • Humans
  • Interleukin-10 / cerebrospinal fluid
  • Interleukin-6 / cerebrospinal fluid
  • Interleukin-8 / cerebrospinal fluid
  • Male
  • Meningitis, Bacterial / cerebrospinal fluid*
  • Meningitis, Bacterial / drug therapy*
  • Middle Aged
  • Vietnam
  • Young Adult

Substances

  • Anti-Inflammatory Agents
  • Interleukin-6
  • Interleukin-8
  • Interleukin-10
  • Dexamethasone