G-quadruplex recognition by macrocyclic hexaoxazole (6OTD) dimer: greater selectivity than monomer

Chem Commun (Camb). 2009 Nov 14:(42):6481-3. doi: 10.1039/b910242f. Epub 2009 Sep 14.

Abstract

Macrocyclic hexaoxazole (6OTD) dimers were designed as candidates for potent G-quadruplex binders and synthesized.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Dimerization
  • G-Quadruplexes*
  • Macrocyclic Compounds / chemical synthesis
  • Macrocyclic Compounds / chemistry*
  • Oxazoles / chemical synthesis
  • Oxazoles / chemistry*
  • Spectrometry, Mass, Electrospray Ionization
  • Telomere / chemistry
  • Telomere / metabolism

Substances

  • Macrocyclic Compounds
  • Oxazoles