Changing the paradigm in conducting randomized clinical studies in advanced pancreatic cancer: an opportunity for better clinical development

MeSH terms

• Antineoplastic Combined Chemotherapy Protocols / administration & dosage*
• Antineoplastic Combined Chemotherapy Protocols / adverse effects
• Capecitabine
• Clinical Trials, Phase II as Topic
• Clinical Trials, Phase III as Topic
• Deoxycytidine / administration & dosage
• Deoxycytidine / adverse effects
• Deoxycytidine / analogs & derivatives
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Female
• Fluorouracil / administration & dosage
• Fluorouracil / adverse effects
• Fluorouracil / analogs & derivatives
• Follow-Up Studies
• Forecasting
• Gemcitabine
• Humans
• Male
• Maximum Tolerated Dose
• Neoplasm Invasiveness / pathology*
• Neoplasm Staging
• Pancreatic Neoplasms / drug therapy*
• Pancreatic Neoplasms / mortality*
• Pancreatic Neoplasms / pathology
• Patient Selection
• Randomized Controlled Trials as Topic
• Survival Analysis
• Time Factors