Bipolar hypertrophic herpes: an unusual presentation of acyclovir-resistant herpes simplex type 2 in a HIV-infected patient

Sex Transm Dis. 2010 Feb;37(2):126-8. doi: 10.1097/OLQ.0b013e3181bcaf91.

Abstract

Hypertrophic pseudo tumoral herpetic lesion is an uncommon presentation in immunocompromized hosts that can be refractory to established therapies. We describe bipolar anal and tonsilar herpetic tumoral lesions related to acyclovir-resistant HSV-2 in a human immunodeficiency virus-infected patient. Treatment with valacyclovir, cidofovir, and thalidomide failed and surgical excision was required.

Publication types

  • Case Reports

MeSH terms

  • Acyclovir / pharmacology*
  • Acyclovir / therapeutic use
  • Animals
  • Antiretroviral Therapy, Highly Active
  • Antiviral Agents / pharmacology*
  • Antiviral Agents / therapeutic use
  • Anus Diseases* / complications
  • Anus Diseases* / drug therapy
  • Anus Diseases* / surgery
  • Anus Diseases* / virology
  • Chlorocebus aethiops
  • Drug Resistance, Viral
  • HIV Infections / complications*
  • Herpes Simplex* / complications
  • Herpes Simplex* / drug therapy
  • Herpes Simplex* / pathology
  • Herpes Simplex* / virology
  • Herpesvirus 2, Human* / drug effects
  • Herpesvirus 2, Human* / genetics
  • Herpesvirus 2, Human* / isolation & purification
  • Humans
  • Hypertrophy
  • Male
  • Middle Aged
  • Palatine Tonsil / pathology
  • Palatine Tonsil / virology
  • Pharyngeal Diseases* / complications
  • Pharyngeal Diseases* / drug therapy
  • Pharyngeal Diseases* / pathology
  • Pharyngeal Diseases* / virology
  • Vero Cells

Substances

  • Antiviral Agents
  • Acyclovir