Selective synthesis of 1-functionalized-alkyl-1H-indazoles

Org Lett. 2009 Nov 5;11(21):5054-7. doi: 10.1021/ol902050m.

Abstract

An efficient method for the selective "N1" alkylation of indazoles is described. Use of alpha-halo esters, lactones, ketones, amides, and bromoacetonitrile provides good to excellent yield of the desired N1 products.

MeSH terms

  • Alkylation
  • Catalysis
  • Combinatorial Chemistry Techniques*
  • Indazoles / chemical synthesis*
  • Indazoles / chemistry
  • Molecular Structure

Substances

  • Indazoles