Total synthesis of (-)-huperzine A

Org Lett. 2009 Nov 19;11(22):5354-6. doi: 10.1021/ol9022408.

Abstract

The total synthesis of (-)-huperzine A was accomplished in 23 steps from a commercially available anhydride. Our synthetic route features a facile construction of the bicyclo[3.3.1] skeleton equipped with proper functionalities to introduce the remaining substructures.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids
  • Cyclization
  • Molecular Structure
  • Sesquiterpenes / chemical synthesis*
  • Sesquiterpenes / chemistry
  • Stereoisomerism

Substances

  • Alkaloids
  • Sesquiterpenes
  • huperzine A