Novel 1D chain Fe(III)-salen-like complexes involving anionic heterocyclic N-donor ligands. Synthesis, X-ray structure, magnetic, (57)Fe Mössbauer, and biological activity studies

Dalton Trans. 2009 Nov 28:(44):9870-80. doi: 10.1039/b912676g. Epub 2009 Oct 2.

Abstract

The iron(III) salen-type complexes [Fe(salen)(L)](n) (1-6) involving heterocyclic N-donor ligands HL {HL = 1H-imidazole (Himz), 1H-tetrazol-5-amine (Hatz), 5-methyl-1H-tetrazole (Hmtz), 1H-benzimidazole (Hbimz), 1H-1,2,4-triazole (Htriz) and 1H-benzotriazole (Hbtriz)} have been prepared and characterised by elemental analysis, FT IR, CI mass and (57)Fe Mössbauer spectroscopies, and variable temperature magnetic measurements. Single crystal X-ray analysis of [Fe(salen)(btriz)](n) (6) revealed a 1D chain-polymeric structure of the complex with the btriz anion as a bridging ligand. Magnetic data for all complexes were fitted using Fisher's model (for S = 5/2) and also using a heptanuclear closed ring model showing a weak antiferromagnetic interaction (J approximately -1 to -2 cm(-1)), and moreover, molecule-based magnet properties have been observed in the case of [Fe(salen)(atz)](n) (2). The exponential correlation between the magnetic properties (the isotropic exchange parameter J) and the basicity of the free ligands (K(b)) has been found. The antiferromagnetic ordering as well as a moderate structural dissimilarity in the vicinity of iron atoms has been proved by the (57)Fe Mössbauer low-temperature (2 K) in-field (7 T) experiments in the case of (2), in which two sextets with the line intensities (3/4/1/3/4/1) have been observed. The compounds have been tested for their SOD-like activity, DNA cleavage activity, and in vitro cytotoxicity against two human cancer cell lines: chronic myelogenous erythroleukemia (K562) and breast adenocarcinoma (MCF7). The best result regarding the cytotoxicity has been achieved for the complex of [Fe(salen)(atz)](n) (2), where IC(50) = 6.4 microM against K562.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / metabolism
  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology
  • Breast Neoplasms / metabolism
  • Cell Line, Tumor
  • Cell Proliferation / drug effects*
  • Crystallography, X-Ray
  • DNA Cleavage
  • Ferric Compounds / chemical synthesis
  • Ferric Compounds / chemistry*
  • Ferric Compounds / pharmacology
  • Humans
  • Iron / chemistry*
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / metabolism
  • Ligands
  • Spectroscopy, Mossbauer
  • Superoxide Dismutase / pharmacology

Substances

  • Antineoplastic Agents
  • Ferric Compounds
  • Ligands
  • Iron
  • Superoxide Dismutase