Pacemaker and defibrillator lead extraction: predictors of mortality during follow-up

Pacing Clin Electrophysiol. 2010 Feb;33(2):209-16. doi: 10.1111/j.1540-8159.2009.02601.x. Epub 2009 Nov 2.

Abstract

Background: Extraction of cardiac implantable electric devices is an accepted procedure when systems become infected or malfunction. However, there is an associated morbidity and mortality. We report our 5-year experience and identify predictors of mortality, and long-term follow-up.

Methods: We analyzed extraction data from January 2003 to November 2007. Extraction methods used were: locking stylets, telescoping sheaths +/- laser, and femoral work stations.

Results: One hundred and eighty-three cases were referred, aged 65 +/- 16 years (range 28-83); 76% were males. Mean implant time was 75 months (range 4-312 months) and indications were: pocket infection (48%), nonfunctioning lead (22%), erosion through skin (18%), endocarditis/septicemia (11%), bilateral superior vena cava thrombosis (0.5%), and painful lead (0.5%). The number of leads extracted were 369, with complete removal in 90.7% and partial in 7.6%. There were no intraoperative deaths but five (2.7%) died within the same admission as their extraction from overwhelming sepsis. Twelve deaths (6.6%) occurred during an average follow-up of 965 days (range 40-1670). Multivariate logistic regression demonstrated that C-reactive protein preprocedure was predictive of acute in-hospital mortality.

Conclusions: Intravascular lead extraction is a safe and efficient method of removing leads. However, there is a subgroup of patients with systemic sepsis with raised inflammatory markers who are at high risk of in-hospital mortality. Long-term follow-up demonstrates mortality which is a marker of the underlying etiology for device implantation, with heart failure patients particularly at risk.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • C-Reactive Protein / analysis*
  • Defibrillators, Implantable / microbiology*
  • Device Removal / methods*
  • Device Removal / mortality*
  • Electrodes, Implanted
  • Endocarditis / mortality
  • Equipment Failure*
  • Female
  • Heart Failure / mortality
  • Hospital Mortality*
  • Humans
  • Male
  • Middle Aged
  • Pacemaker, Artificial / microbiology*
  • Prognosis
  • Risk Factors
  • Sepsis / mortality

Substances

  • C-Reactive Protein