Abstract
Treponema pallidum resistance to azithromycin has been documented in the US, Canada, and Ireland. We found no evidence of resistance to azithromycin in specimens from 141 patients with syphilitic lesions in Madagascar suggesting resistance is geographically isolated and supporting use of azithromycin as alternative treatment for early syphilis in Madagascar.
Publication types
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Clinical Trial, Phase III
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Multicenter Study
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Randomized Controlled Trial
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Research Support, N.I.H., Extramural
MeSH terms
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Adolescent
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Adult
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Anti-Bacterial Agents / pharmacology*
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Anti-Bacterial Agents / therapeutic use
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Azithromycin / pharmacology*
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Azithromycin / therapeutic use
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Bacterial Proteins / genetics
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Drug Resistance, Bacterial* / genetics
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Female
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Humans
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Madagascar / epidemiology
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Male
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Microbial Sensitivity Tests
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Middle Aged
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Mutation
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RNA, Ribosomal, 23S / genetics
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Syphilis / drug therapy
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Syphilis / epidemiology*
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Syphilis / microbiology
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Treponema pallidum / drug effects*
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Treponema pallidum / genetics
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Young Adult
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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RNA, Ribosomal, 23S
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Azithromycin