Abstract
The first fluorinated analogue of the naturally occurring 2,4-methanoproline, 4-fluoro-2,4-methanoproline, has been synthesized in five steps from commercially available methyl 2-fluoroacrylate through a photochemical cyclization as a key step in generating a 2-azabicyclo[2.1.1]hexane skeleton.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Azabicyclo Compounds / chemical synthesis*
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Azabicyclo Compounds / chemistry
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Catalysis
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Cyclization
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Hydrocarbons, Fluorinated / chemical synthesis*
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Hydrocarbons, Fluorinated / chemistry
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Molecular Structure
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Proline / analogs & derivatives*
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Proline / chemical synthesis
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Proline / chemistry*
Substances
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Azabicyclo Compounds
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Hydrocarbons, Fluorinated
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Proline