Abstract
Background:
There is a need for simple imaging parameters capable of predicting therapeutic outcome.
Methods:
This retrospective study analysed 50 patients with locally advanced carcinoma of the cervix who underwent dynamic contrast-enhanced MRI before receiving potentially curative radiotherapy. The proportion of enhancing pixels (E(F)) in the whole-tumour volume post-contrast agent injection was calculated and assessed in relation to disease-free survival (DFS).
Results:
Tumours with high E(F) had a significantly poorer probability of DFS than those with low E(F) (P=0.011).
Interpretation:
E(F) is a simple imaging biomarker that should be studied further in a multi-centre setting.
Publication types
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Evaluation Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenocarcinoma / blood supply
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Adenocarcinoma / radiotherapy
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Adult
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Aged
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Aged, 80 and over
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Carcinoma, Adenosquamous / blood supply
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Carcinoma, Adenosquamous / radiotherapy
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Carcinoma, Squamous Cell / blood supply*
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Carcinoma, Squamous Cell / mortality
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Carcinoma, Squamous Cell / radiotherapy
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Contrast Media*
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Disease-Free Survival
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Female
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Follow-Up Studies
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Gadolinium DTPA*
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Humans
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Image Processing, Computer-Assisted / methods*
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Image Processing, Computer-Assisted / statistics & numerical data
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Kaplan-Meier Estimate
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Magnetic Resonance Imaging / methods*
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Middle Aged
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Neoplasm Metastasis
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Neoplasm Recurrence, Local / epidemiology
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Neoplasm, Residual
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Neovascularization, Pathologic / pathology*
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Retrospective Studies
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Uterine Cervical Neoplasms / blood supply*
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Uterine Cervical Neoplasms / mortality
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Uterine Cervical Neoplasms / radiotherapy
Substances
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Contrast Media
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Gadolinium DTPA