A case of persistent visual hallucinations of faces following LSD abuse: a functional Magnetic Resonance Imaging study

Neurocase. 2010 Apr;16(2):106-18. doi: 10.1080/13554790903329141. Epub 2009 Nov 18.

Abstract

In this study, we report the case of a patient experiencing hallucinations of faces that could be reliably precipitated by looking at trees. Using functional Magnetic Resonance Imaging (fMRI), we found that face hallucinations were associated with increased and decreased neural activity in a number of cortical regions. Within the same fusiform face area, however, we found significant decreased and increased neural activity according to whether the patient was experiencing hallucinations or veridical perception of faces, respectively. These findings may indicate key differences in how hallucinatory and veridical perceptions lead to the same phenomenological experience of seeing faces.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antipsychotic Agents / therapeutic use
  • Brain Mapping
  • Chronic Disease
  • Disability Evaluation
  • Face
  • Functional Laterality / drug effects
  • Functional Laterality / physiology
  • Hallucinations / chemically induced*
  • Hallucinations / diagnosis
  • Hallucinations / physiopathology*
  • Hallucinogens / adverse effects*
  • Humans
  • Lysergic Acid Diethylamide / adverse effects*
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Neuropsychological Tests
  • Pattern Recognition, Visual / drug effects
  • Pattern Recognition, Visual / physiology
  • Photic Stimulation
  • Psychotic Disorders / complications
  • Serotonin Agents / adverse effects
  • Temporal Lobe / anatomy & histology
  • Temporal Lobe / drug effects
  • Temporal Lobe / physiopathology
  • Time
  • Visual Cortex / anatomy & histology
  • Visual Cortex / drug effects*
  • Visual Cortex / physiopathology*
  • Visual Pathways / anatomy & histology
  • Visual Pathways / drug effects
  • Visual Pathways / physiopathology

Substances

  • Antipsychotic Agents
  • Hallucinogens
  • Serotonin Agents
  • Lysergic Acid Diethylamide