CTX-M beta-lactamase production and virulence of Escherichia coli K1

Emerg Infect Dis. 2009 Dec;15(12):1988-90. doi: 10.3201/eid1512.090928.

Abstract

We report a patient with neonatal meningitis caused by a CTX-M-1-producing Escherichia coli K1 strain. The influence of CTX-M production on virulence was investigated in cell culture and a newborn mouse model of meningitis. CTX-M production had no influence on virulence but was a major factor in clinical outcome.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Animals
  • Escherichia coli / enzymology*
  • Escherichia coli / pathogenicity
  • Female
  • Humans
  • Infant, Newborn
  • Meningitis, Bacterial / etiology*
  • Mice
  • Pregnancy
  • Virulence
  • beta-Lactamases / biosynthesis*

Substances

  • beta-lactamase TEM-3
  • beta-Lactamases