Complete resolution of universal calcinosis in a patient with juvenile dermatomyositis using pamidronate

Joint Bone Spine. 2010 Jan;77(1):70-2. doi: 10.1016/j.jbspin.2009.04.011. Epub 2009 Dec 23.

Abstract

A 14-year-old girl with juvenile dermatomyositis developed extensive and debilitating calcinosis, unresponsive to colchicine, while muscle involvement subsided. Pamidronate (2mg/kg/year) produced dramatic improvement of pain and function within 2 months and calcinosis had completely resolved by 2 years. No new calcifications have been noted with a 5-year follow-up.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Bone Density Conservation Agents / therapeutic use*
  • Calcinosis / diagnostic imaging
  • Calcinosis / drug therapy*
  • Calcinosis / etiology
  • Calcium / administration & dosage
  • Cholecalciferol / administration & dosage
  • Dermatomyositis / complications
  • Dermatomyositis / diagnostic imaging
  • Dermatomyositis / drug therapy*
  • Diphosphonates / therapeutic use*
  • Drug Therapy, Combination
  • Female
  • Humans
  • Methylprednisolone / therapeutic use
  • Pamidronate
  • Radiography
  • Recovery of Function
  • Treatment Outcome

Substances

  • Bone Density Conservation Agents
  • Diphosphonates
  • Cholecalciferol
  • Pamidronate
  • Calcium
  • Methylprednisolone