The proliferative response to CpG-ODN stimulation predicts PFS, TTT and OS in patients with chronic lymphocytic leukemia

Michela Tarnani; Luca Laurenti; Pablo G Longo; Nicola Piccirillo; Stefania Gobessi; Alice Mannocci; Sara Marietti; Simona Sica; Giuseppe Leone; Dimitar G Efremov

doi:10.1016/j.leukres.2009.12.020

The proliferative response to CpG-ODN stimulation predicts PFS, TTT and OS in patients with chronic lymphocytic leukemia

Leuk Res. 2010 Sep;34(9):1189-94. doi: 10.1016/j.leukres.2009.12.020. Epub 2010 Jan 13.

Authors

Michela Tarnani¹, Luca Laurenti, Pablo G Longo, Nicola Piccirillo, Stefania Gobessi, Alice Mannocci, Sara Marietti, Simona Sica, Giuseppe Leone, Dimitar G Efremov

Affiliation

¹ Department of Haematology, Catholic University Hospital "A. Gemelli", Largo A. Gemelli, 8, 00168 Rome, Italy.

PMID: 20074801
DOI: 10.1016/j.leukres.2009.12.020

Abstract

We recently reported that leukemic cells from IgVH-unmutated/progressive CLL more frequently proliferate in response to CpG-ODN stimulation than their corresponding counterparts. Here we evaluated the prognostic impact of this proliferative response in 91 CLL patients. The proliferative response was highly predictive of PFS, TTT and OS in the whole series and refined prognosis in patients with M-CLL. BCR stimulation modulated the response to CpG-ODN, suggesting that the proliferative capacity of the leukemic cells is related to antigen-encounter history. These data support the hypothesis that the capacity of the leukemic cells to respond to external stimuli influences disease progression in CLL.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Proliferation*
CpG Islands*
Female
Humans
In Situ Hybridization, Fluorescence
Leukemia, Lymphocytic, Chronic, B-Cell / pathology*
Male
Multivariate Analysis
Oligodeoxyribonucleotides / pharmacology*
Survival Analysis*

Substances

Oligodeoxyribonucleotides